Tag: steroid ester half life

What Is A Steroid Ester?

January 11, 2019

steroid ester

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The role of esters

One of the most misunderstood topics in the world of steroids is the role of esters — injectable esterifying steroids like cypionate testosterone, enanthate testosterone, and Sustanon. If you take a quick look at the Internet, you may find countless articles suggesting that one form of steroid is more effective than another. The debate on whether cypionate is better than enanthate, or Sustanon is better than all the other testosterone is, of course, fairly general. Such an argument is completely practical and groundless. In this report, we will study esters and their specific effects on steroids with authority.

What is ester and how does it work

I’m sure if you’re interested in anabolic steroids you’ll notice a lot of similarities on the labels. Let’s take testosterone for example. We can find compounds like cypionate, enanthate, propionate, phenylpropionate, isocaproate, decanoate. In all these cases, the maternal hormone is testosterone and is changed by the addition of esters (enanthate, propionate, etc.) to its structure. The next question is: what are the differences in the use of esterified testosterone for exercise?

An injectable anabolic/androgen esterification basically does one thing, it slows the release of the maternal steroid from the injection site. This is because esters significantly reduce the water solubility of steroids and increase their lipid solubility (fat). This causes the drug to form a deposit in the muscle tissue, and when a small amount is absorbed into the blood stream, the drug slowly enters the circulation. In general, the longer the ester chain, the lower the water solubility of the compound, and the longer the time required to reach the full cycle.

With the addition of esters, patients can see their doctors for injections infrequently once a month, rather than having to constantly readminister them for therapeutic effect. Obviously, without the use of esters, the injection of anabolic/androgen therapy would be much more difficult.

Esterification temporarily inactivates steroid molecules. Since the 17th beta site is blocked by a chain, it is unlikely to bind to the androgen receptor (which does not have any activity in the body). Therefore, in order for the compound to be active, the ester must first be removed. Once the compound is in the bloodstream, the esterase breaks down (hydrolyzes) the ester chain quickly, and the reaction occurs automatically. This will restore the necessary hydroxyl (OH) at the 17th beta site, allowing the drug to attach to the appropriate receptor. Only then

Steroids can affect skeletal muscle tissue. You can start to see why it doesn’t make sense to think that cypionate is more effective than enanthate, because all your muscles see is free testosterone, no matter what ester it’s developed with.

Different esters

There are many different esters in anabolic/androgen steroids, but their action is essentially the same. Esters differ in their ability to reduce the water-solubility of steroids. For example, esters like propionate slow the release of steroids by a few days, while decanates take weeks.


The advent of esters is certainly a valuable advance in the field of anabolic steroids, but as you can clearly see, there is nothing magical about it. Esters act in a well understood and predictable manner and do not alter the activity of the parent steroid in any way other than delayed release. Although the allure of various steroid products, like cypionate testosterone, Sustanon, Omnadren and others, is certainly going to prompt interesting conversations, it’s actually just the wrong message that athletes are best to ignore. Testosterone is testosterone, and anyone who wants to tell you that this (or any) ester hormone is much better than the other should do more research and talk less.