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The Use of HCG During Steroid Cycles

March 13, 2019

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Q: “How can I best use HCG during steroid cycles?”
A: My most common recommendation with HCG is to use it only during cycles to avoid testicular atrophy and to maintain testicular responsiveness. When this is done, then as soon as LH production is restored with SERM use or with time, the testes are immediately responsive to produce testosterone.
However, as your question suggests, HCG can also provide benefit between cycles.

I recommend avoiding HCG for at least the first two weeks after the recovery period has started. By the start of the recovery period, I mean the time point where androgen levels from steroids taken during the cycle have fallen sufficiently to allow LH production to begin to resume. HCG use during this early phase can interfere with recovery of LH. I’m not saying it’s impossible to recover LH production while using HCG, but HCG use impairs the process.

HCG use during recovery does make it impossible to determine by “feel” whether recovery of LH is occurring. LH could be near zero while testosterone is normal or high-normal.
Ideally, a blood test for LH is taken at about 2-4 weeks into the recovery to establish for a fact whether LH production has recovered. This is optional: many don’t do it but instead go simply from how they feel and perform, which can be a good basis if HCG was not used during recovery.

When confident for either of these reasons that a good recovery has occurred, then a bridging, or between cycle, use of HCG can begin. I recommend starting with a modest amount, such as about 250-275 IU 3x/week. At this usage level, a 5000 IU vial lasts 6 weeks.

If you already have been using letrozole or another aromatase inhibitor when off-cycle and have found a dosage suitable for you to maintain ideal estradiol levels (low 20′s pg/mL), then at first use the aromatase inhibitor at that same dosage while using HCG. If you don’t already have information on your estradiol levels, then at first don’t add an aromatase inhibitor. Save it for when you have blood test results.

HCG use between cycles is one time that blood work really should be taken more seriously than it commonly is. If wanting to use HCG between cycles, I strongly recommend against guesswork. If it’s gotten wrong, then LH production will be shut down not only during the cycles, but in most of the off weeks as well. For the hypothalamus and pituitary, it can become the equivalent of using steroids almost every week of the year.

In most cases when estradiol is kept at a good level, normal LH production can be maintained while using HCG at about 200-275 IU 3x/week. This can provide substantially higher testosterone levels, typically high-normal, than when HCG is not used. The benefit between cycles can be noticeable, with no adverse side effects at all.

About 2 weeks into HCG use, LH and estradiol should be tested. If estradiol is outside the low 20′s pg/mL range, aromatase use should be adjusted. If estradiol is good but LH is low, HCG use should be decreased, for example to 250 IU twice per week.

Where estradiol and LH levels are good, optionally HCG dosage may be increased. There’s no reason to go past about 1500 IU/week, as further benefit past that level is unlikely. Retesting should be performed after each adjustment of HCG dose.


Human Chorionic Gonadotrophin (HCG)

March 13, 2019

hcg, hormones, Peptide

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Human chorionic gonadotrophin (HCG) is a strange hormone. Its only found in the placenta of pregnant women. For women it has fairly little use if any however, but to the male athlete it has one interesting property. It can mimic the action of luteinizing hormone (LH) in the body. LH is a pituitary hormone that is released and signals the manufacture of testosterone in the testicles. The sex hormones in the body work via a negative feedback system, where too much sex hormone (like anabolic androgenic steroids and estrogens) causes a signal to the brain to stop the release of LH. During long duration cycles, if natural test stays suppressed for considerable time, a male user will begin to note an atrophy in his testicles, meaning they will visibly shrink purely out of disuse. By administering an LH-mimicking agent, one can bring back the function of the testicles and let them regain their size. This is the main use of HCG.

Since it forms testosterone in the body to some extent, it can impart certain performance enhancing properties, but usually these are not major. The side-effects accompanied with HCG use (usually androgenic such as extreme acne), its low rate of effect, the cost compared to more effective steroids and so on will mostly keep athletes from using it for that purpose. Moreover it can be tested for in athletic competitions, so most will stay clear of it. But to the steroid user HCG is an almost essential part of a cycle. Because of its effect on bringing testicle size back it can promote the return of natural testosterone, since the first natural signals can immediately deliver a higher yield of testosterone in the body. And getting natural testosterone back online after a cycle is crucial, especially if you intend to keep most of your hard-earned gains. Without adequate natural endocrine response you will not be able to maintain a mass that was higher than before.

The downside is that HCG too is suppressive of natural testosterone. Because it takes the place of LH. LH is not the first step in the chain of command, instead its manufactured in the pituitary under the response of Gonadotropin releasing hormone (GnRH) which is secreted from the hypothalamus. And since an LH mimicking agent is supplied exogenously, the negative feedback signal to the hypothalamus will still tell it to stop making GnRH, and so no natural LH is produced. This is why the product is always used in conjunction with a potent estrogen receptor antagonist like clomid or Nolvadex. When the androgen level in the body has dropped, these antagonists will lower estrogenic response creating a steroid deficit that signals the Hypothalamus to start making GnRH. When it does, after HCG therapy, testicle size is up again and shortly thereafter natural testosterone manufacture should return to normal. But therefore its crucial that users note that though HCG is essential after long cycles, it shouldn’t be used without clomid or Nolvadex AND HCG should be discontinued at least two weeks before coming off Clomid or Nolvadex or else it will suppress natural testosterone itself.

Also important to take into account : using HCG for too long a period of time or in doses that are excessively high, can desensitize the testicles to the effect of LH and would put your right back where you started from. Basically that would mean you spent money to no avail. In terms of side-effects one should expect some androgenic signs such as acne and there is a risk for hair loss or prostate hypertrophy, but in most cases this compound will be used for 3-4 weeks, so these should not manifest themselves to any serious degree. There will also be some estrogen build-up, but since the user HAS to be on clomid or Nolvadex, this should not become apparent either. Next to this, HCG being a fertility drug, one should be aware that increased blood pressure and blood clotting can occur. HCG is clinically used to make women ovulate, or to invoke birth in pregnant women.

You would normally opt to use HCG after you’ve done a long cycle, usually 8 weeks or more. Note that almost all proper cycles are 8 weeks or more in length, its just that some beginners have a phobia of needles and opt to waste their time with an all oral stack first, in which case the cycle wouldn’t be longer than 6-7 weeks. In these cases too HCG can have a use, but most of the time testicular atrophy will not have progressed to such a stage that it is an absolute necessity. In any case, you should run it about 3 weeks, totaling about 4 shots. One every 5-6 days. Start off with one shot of 3000 IU somewhere in the last week of your stack, then another 3000 5 days later, then drop to 1500 5 days later and a last shot of 1500 6 days after that. Sometime after the second or third shot, therapy with Nolvadex or clomid should be commenced and continued for 4-5 weeks. How to do this, I refer you to the Nolva/clomid profile.

In any case, I’ll repeat it again, since it is important. HCG IS and always will be an important part of post-cycle recovery, but it should never be run too long or at too high a dose and should always be accompanied by the use of either Clomid or Nolvadex. The use of Clomid or Nolvadex should also be continued at least 2 weeks after HCG is discontinued to avoid the rebound loop back effect.


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HCG Profile

Human growth hormone is a protein hormone composed of 191 amino acids, produced by the pituitary gland. It is responsible for protein deposition, tissue growth and the breakdown of subcutaneous fat storage. The highest levels of human growth hormone are produced during puberty, which is not surprising since this is the main stage of a person’s physical development. Growth hormone still circulates throughout adulthood, but at much lower levels. The main medical purpose of giving people growth hormone is to treat those who lack it during puberty so that they can grow normally. In recent years, however, human growth hormone has surged in popularity as a treatment for age-related degenerative diseases and other so-called “anti-aging” treatments.

Human growth hormone first appeared in the 1980s. At first, it was taken from the pituitary gland of a corpse. However, the practice stopped when it was determined that hormones collected in this way were linked to the spread of a deadly brain disease. All human growth hormones produced today are synthetic.

Function of HCG

In terms of the use of HGH by strength athletes and bodybuilders, the effects are twofold. First, continued use of HGH has been shown to help promote the loss of body fat. This is partly because the compound allows the body’s cells to use fat more quickly and carbohydrates less quickly. This fat loss occurs because growth hormone stimulates the hydrolysis of triglycerides in adipose tissue.

At the same time, HGH helps promote the movement of amino acids across cell membranes. This, combined with the fact that growth hormone promotes the growth of cells in the body, increases the rate at which these cells divide and proliferate, clearly suggests that it can also enhance anabolism if given the right dose.

Many users are also interested in the ability to use human growth hormone to help treat existing injuries and prevent new ones from occurring. There is evidence that when used in combination with insulin-like growth factor, growth hormone promotes the regeneration and regeneration of damaged cartilage. It’s actually insulin-like growth factor that stimulates cartilage production. Insulin-like growth factor is released from the liver under the action of circulating growth hormone.

Studies have also shown that human growth hormone has a positive effect on erythropoiesis. This effect should help increase endurance in athletes and may also help promote anabolism. The impact varies widely among users, but all users should improve.

Human growth hormone is secreted mainly during the rhythmic impulses of sleep. This is caused by the alternate release of growth hormone releasing hormone and somatostatin. In most cases, users will want to mimic the natural release of growth hormone without disrupting the body’s naturally occurring hormones. It’s usually a delicate balance.

How to use HCG

There is some debate about the optimal fat loss/anabolic approach regarding the timing of administration of the compound. Many people believe that the daily dose is the most important when using HGH because the active life of the drug is very short. Two to six hours after the injection, blood hormone levels peak, with a half-life of only 20-30 minutes. This, of course, makes it impossible to maintain stable levels of the compounds in the blood.

However, a stable level of hormones seems unnecessary because it does not occur naturally when the body produces hormones. In fact, some studies suggest that injecting the hormone every other day, rather than every day, may make it more effective. One theory for why this happens is that injections every other day mimic the natural pulse rate of growth hormone secretion.