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What is Exemestane

Exemestane is a drug used to treat menopausal women breast cancer.

You may have heard of Aromasin, this is the most famous brand. There are many other brands of Exemestane also have the same dose.

Men with breast cancer can take Exemestane, while another called the drug tamoxifen is more commonly used.

How does Exemestane work

Exemestane is to reduce the effect of estrogen in the body. Exemestane belong to a class of aromatase inhibitors. Exemestane is a kind of aromatase inhibitors. This means it blocks aromatase, an enzyme that converts androgens (hormones produced by the adrenal glands) into estrogen, which is found in the body’s muscles, skin, breasts and fat.

Exemestane Usage

Exemestane is suitable for postmenopausal women estrogen receptor-positive breast cancer patients. If your cancer is hormone-receptor negative, there is no benefit to esimetan.

Exemestane Dosage

Exemestane 25mg every day is suggested.

Exemestane is usually taken after the surgery, in order to reduce the risk of breast cancer recurrence or diffusion.

If you are undergoing chemotherapy or radiotherapy, your specialist will tell you the best time to start taking esimetam.

Sometimes, Exemestane can be used as the first therapy for breast cancer, for example, when the surgery is not appropriate or need to delay. It is sometimes used to shrink larger breast cancers before surgery.

Exemestane can also be used for the treatment of recurrent breast cancer. It can also be used to treat breast cancer (secondary breast cancer) that has spread to other parts of the body, often in combination with another drug.

How long will it take

It depends on your personal circumstances, but Exemestane usually takes 5 to 10 years.

Some people are taking hormone therapy drug Tamoxifen, a few years, Exemestane came into use.

If you’re using it to treat a relapse or if breast cancer has spread to other parts of the body, as long as it controls the cancer, you’ll usually take it.

What should I know about drug storage and disposal?

Keep medicine in a container and keep it sealed away from children. Store at room temperature, away from excess heat and moisture (don’t store in the bathroom).

Exemestane for men

Aromatase inhibitor Exemestane can effectively slow down the boy’s physiological maturity, improve adult male testosterone levels, therefore, aromatase inhibitors can be used to increase the gonads hormone-dependent precocious puberty, idiopathic short and constitutional delayed puberty boy adult height.

Exemestane is better than tamoxifen

A new study finds Aromasin is more effective than Tamoxifen in reducing the risk of breast cancer recurrence, but not all clinicians believe the positive findings. Overall, no cancer survival rates have improved significantly (Exemestane91.1 Tamoxifen87.3 %, %).

 


Exemestane Powder Supplier


Buy Exemestane Canada

Exemestane is a steroid suicide aromatase inhibitor/irreversible aromatase inactivator that reduces estrogen production by blocking aromatase. The medical use of exemestane, like most aromatase inhibitors, is to treat estrogen-dependent breast cancer. It is usually used only when treatment with less aggressive compounds does not produce the desired effect, such as selective estrogen receptor modulators.

For strength athletes and bodybuilders, exemestane has several beneficial characteristics. First, it is reported that exemestane can reduce estrogen by an average of 85%. Of course, doing so helps prevent estrogen-related side effects caused by aromatic steroids. The drug also increases testosterone levels in users, which may be beneficial if used in post-cycle treatment. In addition, there is some evidence that exemestane may increase the level of insulin growth factor (IGF).

Like other aromatase inhibitors, information and Research on the effects of exemestane on lipid/cholesterol in users are conflicting. Some studies have shown that the compound has little effect, while others consider it rather harsh.

Exemestane Dosage

The peak plasma concentration of exemestane was reached within 2 hours after oral administration of 25 mg. The effective life of the drug ranges from 24 to 30 hours. This is important because it is much shorter than non-steroidal inhibitors. A single oral dose of 25 mg of exemestane resulted in a relatively long-term decrease in estrogen levels in plasma and urine. The maximum inhibition occurred about 2 to 3 days after administration and lasted for about 4 to 5 days.

Studies have shown that 25 mg of exemestane is almost as effective as 50 mg in inhibiting estrogen, increasing testosterone and insulin-like growth factor levels. Therefore, the daily dose should not exceed 25 mg. Because of the activity of the compound exemestane, it is administered approximately every 24 hours.

The only negative aspect of the compound seems to be that it takes about seven days to reach a stable plasma level in terms of drug delivery plans. However, this is not the main obstacle to its use. It simply requires users to start using exemestane a week before they expect the compound to be fully effective.

Risk of using exemestane

There was no significant toxicity of exemestane at a daily dose of 600 mg. Most users are well tolerated, and the maximum tolerable dose toxicity has not yet been determined. Negative side effects associated with the use of this compound are usually mild and may include transient gastrointestinal reactions, hot flashes, nausea and/or fatigue. As mentioned earlier, due to conflicting studies, the effect of exemestane on lipid/cholesterol is not yet clear, so monitoring should be carried out when using the compound. Sexual dysfunction is also possible due to lower estrogen levels. However, there are relatively few reports on this aspect.

Because of the minor side effects associated with this compound and its effectiveness in reducing estrogen-related side effects in aromatic steroid synthesis, exemestane seems to be a relatively safe choice in the search for aromatase inhibitors.


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January 16, 2019

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Exemestane for pct cycle

Exemestane is a steroidal aromatase inhibitors/suicide irreversible aromatase inactivator, by blocking aromatase reduces the production of estrogen in the body. The drug, which is structurally similar to formestan, is used in the treatment of estrogen-dependent breast cancer, are most aromatase inhibitors. It is popular among bodybuilders when it was used to the post pct-cycle.

The function of Exemestane

For strength athletes and bodybuilders, Exemestane several useful features. First of all, Exemestane estrogen can be 85% lower. Doing so will certainly help prevent estrogen-related side effects from aromatase steroids. The drug also boosts users’ testosterone levels, which may be beneficial if used during post-cycle therapy. In addition, there is evidence that Exemestane is likely to raise the level of insulin growth factor of IGF.

Effects of Exemestane

Like other aromatase inhibitors, the effects of Exemestane lipid/cholesterol to the users, there are conflicting information and research. Some studies have shown that Exemestane lipid/cholesterol almost has no impact to the user, and the influence of other research shown that it can be rather serious.

Exemestane dosage

After oral 25 milligrams, Exemestane2 hours peak plasma concentration. The effective life of this medicine is between 24 and 30 hours. This is important because it is much shorter than nsaids. Single oral 25 milligrams Exemestane will result in plasma and urine estrogen levels decline in a relatively long time, about 2 to 3 days after taking a maximum inhibition, and last about 4 to 5 days.

Research shows that 25 milligrams of Exemestane improves the level of testosterone and estrogen as welll as levels of IGF is basically as effective as 50 mg. Therefore, a daily dose of more than 25 milligrams is not necessary. Due to the activity of Exemestane, it is suggested taking it about every 24 hours.

The only negative effect of the compound from the dose plan is that it takes about seven days to reach stable plasma levels. However, this is not the main barrier to its use. It simply needs a week before the users fully realize the effect of compound Exemestane came into use.

Side effects when using Exemestane

Exemestane under the dose of 600 mg/day is no significant drug toxicity. Most users are well tolerated and the maximum tolerable dose of toxicity has not been determined. Adverse side effects associated with the use of this compound are usually very mild and may include transient gastrointestinal reactions, hot flashes, nausea and/or fatigue. As noted earlier, the effect of esimetan on lipids/cholesterol is unknown and should therefore be monitored when the compound is used.

Review

Exemestane is a relatively safe in aromatic steroid inhibitors, due to the compound has a moderate negative side effects, should be used under the guidance.