Oral Turinabol is a steroid that has a reputation among bodybuilders. It was originally developed by east German scientists for use by their Olympic athletes. The success of those athletes proves its effectiveness. In fact, it is widely used to improve athletic performance, which means that it has been affected by many experiments, and the documented results are very impressive.
Characteristic of oral Turinabol
It really gives the muscles a good workout. While muscle strength and gain are not as dramatic as other compounds, they are unlikely to be accompanied by water retention. That means you’re more likely to hold on to whatever gains you get at the end of a cycle. In addition, oral Turinabol does not produce estrogen-related side effects (such as male breast development). Although it is alkylated with 17-alpha, this means it is toxic to the liver. Therefore, it is advisable to use some form of liver support in circulation (e.g., Silymarin, Dandelion, NAC).
Oral Turinabol is described as a derivative of Dianabol, although its androgen activity is much lower. This means it won’t make you look as puffy as those who use Dianabol. In fact, many users have already compared it to Anavar in terms of results.
Side effects of Turinabol
The substance has few side effects and usually the result of too long a cycle or too high a dose leads to side effects. The above risk of hepatotoxicity and reduced blood clotting capacity are the only things to note. It’s also associated with a natural drop in testosterone levels, but it’s usually dose-related. It has been reported that women suffer more side effects when using the substance than men, but these reactions are more common in women. Why? They take almost twice as much as men, so they certainly have more side effects.
It is recommended that men take 20-40 milligrams a day and women 5-10 milligrams a day. In real life, however, male bodybuilders generally prefer 0.4 milligrams per pound.
One interesting aspect of oral Turinabol is that it lowers SHBG. It binds to other steroid hormones, causing the body to release more testosterone. For this, many athletes find it an important adjuvant to any cycle? Especially those who use testosterone. The fact that oral Turinabol is not associated with aromatization (that is, conversion to estrogen) also adds to its appeal.
In short, when you consider that it produces few annoying side effects (at reasonable doses) and that muscle mass improves over time with high quality, oral Turinabol is definitely worth considering as it is part of an effective circulation. Even when used alone, it is sure to yield significant improvements in quality and strength. This increase would not be surprising, but it would be easier to maintain because the improvement in oral Turinabol was not an illusion of water weight.
Sustanon 250 profile
Sustanon 250 is primarily used for hormone replacement therapy, a mixture of testosterone esters that is thought to provide long-term testosterone release. It is thought that by using short, medium and long acting esters, the stable flow of the compound can be maintained and very infrequent injections will be required. However, this theory turned out to be wrong, because over time, the complex peaks in the blood decreased rapidly and slowly. To maintain stable blood levels, the drug must be injected as often as other short esters.
Sustanon 250 composition
Sustanon 250 was mixed with esters of testosterone in doses of 30mg propionic acid, 60mg phenylpropionic acid, 60mg isopropionic acid and 100mg decanoic acid. It should also be noted that there is a Sustanon 100. It is: 20mg propionic acid, 40mg phenylpropionic acid and 40mg isopropionic acid. Since Sustanon 100 does not contain decanoate, the active life of the compound is shorter than that of Sustanon 250. Apart from this difference, the compounds are quite similar.
Compared to other testosterone steroid
Sustanon 250, in addition to the ester compounds, has no distinct advantage over other testosterone compounds. The effect should be much the same as that of any testosterone compound. In terms of the effect of esters, Sustanon 250 appears to be the most detrimental. Many users have complained of water-retention problems with long-acting esters, but the compound should be injected regularly due to the presence of long-acting esters. This leads many users to choose another testosterone ester that is better designed for their target.
Testosterone promotes strength and muscle growth through a number of mechanisms. First, testosterone promotes the retention of nitrogen in muscles, which allows them to store more protein and promote the repair and growth of these muscles. Secondly, testosterone binds to androgen receptors, promoting receptor-dependent mechanisms of muscle growth and fat loss. Testosterone also helps increase the concentration of androgen receptors in cells, which are essential for muscle growth and repair.
As mentioned earlier, testosterone plays a role in promoting fat loss. Testosterone binds to androgen receptors in fat cells. This breaks down body fat and prevents the formation of new fat. Of course, since testosterone promotes muscle growth, it also indirectly promotes fat loss, since any excess calories could be used to build muscle rather than as body fat.
Like most anabolic steroids, testosterone increases the production of red blood cells. An increase in the number of red blood cells in the blood can improve endurance through better oxygenated blood, as well as the user’s ability to recover after strenuous exercise. It should be noted, however, that there are other steroids and compounds that are much more adept at this function.
Other mechanisms by which testosterone helps promote anabolism include its role in promoting the growth of insulin factor 1 and inhibiting the release of catabolic hormones in the body. Testosterone also has many advantages when it comes to improving performance. That is, it has the ability to increase the number of muscle motor neurons, which improves muscle contraction. Like many other anabolic steroids, testosterone promotes glycogen synthesis. This, of course, helps increase the user’s endurance and strength by providing more fuel for high-intensity exercise.
Like other testosterone compounds, the drug dose a user takes depends largely on the user’s experience and goals. Testosterone users with doses as low as 200-250 mg/week reported good results, with experienced users taking several grams of testosterone per week. It is widely used. That includes women taking testosterone. Since some of the esters in Sustanon 250 have a longer active life, it is not recommended that women take Sustanon 250 or other long-acting formulations.
Anastrozole is an aromatase inhibitor. Aromatase inhibitors prevent the conversion of androgens from fat, muscle, breast and brain into estrogen. The main medical use of anastrozole is to inhibit the progression and growth of breast cancer in women by blocking aromatase. It is also used by some doctors to treat testosterone deficiency in men and in combination with testosterone replacement therapy.
For bodybuilders and strength athletes, anastrozole is used to reduce the aromatization of anabolic steroids, in part because it boosts users’ testosterone levels. By reducing the amount of estrogen in a steroid user’s body, he will be able to avoid estrogen-related side effects, such as water retention and breast development in women.
Interestingly, in addition to lowering estrogen, anastrozole also increased testosterone levels by 58 percent, as well as increasing levels of the moisturizing hormone. This is very important. Considering that anastrozole can be used in combination with other compounds, it can increase users’ natural testosterone levels in the post-cycle.
Anastrozole powder uses
In most users, 0.5 mg per day should be sufficient to prevent estrogenic side effects associated with anabolic steroid use. Even when the dose was increased to 1 mg per day there was no change in the amount of estrogen compared to 0.5 mg per day. This suggests that if estrogen side effects are still a problem at 0.5mg, increasing your dose will have no further effect. If symptoms persist, users may have to try a more potent compound, such as femara.
However, most users can reduce any water retention or other estrogen-related side effects they may have by taking a dose less than 0.5 mg per day. Interestingly, users reported that a dose of 0.25 mg daily or 0.5 mg every other day was sufficient to achieve this result. It is possible to take anastrozole every other day because it has 48 hours of activity.
The same dose of anastrozole should be used in patients who take anastrozole during the postcycle treatment period. There is no need to increase or decrease the dose. It can run the entire post-cycle without any adverse effects.
Blood levels of the compound should stabilize and peak 7 to 10 days after the first dose. As a result, it is unlikely that users will have to load anastrozole in advance or start using it before they start managing the anabolics they plan to use.
Side effects of taking Arimidex
Arimidex appears to have a mild effect on blood lipids (cholesterol) and has not been shown to have a negative effect on blood lipids (cholesterol). However, it should be noted that if a person consistently suppresses your natural estrogen levels over a long period of time, this could have negative effects on your health (including your cholesterol). Nevertheless, there is no scientific evidence that anastrozole is dangerous for healthy individuals, even in the long term.
It appears that the use of anastrozole has few side effects. It is by far one of the safest compounds available to athletes. It helps to increase natural testosterone levels.
Ostarine (MK-2866) is a SARM(selective androgen receptor modulator) originally used to treat and prevent muscle atrophy. Bodybuilders can and should observe the same increase in strength. It has tissue selective anabolism in muscle and bone. Austin is one of the best muscle groups for anabolism.
Depending on the quality of the diet, it is not unreasonable to use a higher dose over an 8-week period to look at 6-10 pounds of high-quality leen muscle mass.
Ostarine MK-2866 works by allowing more protein to be synthesized to form new muscle tissue. Sarms such as Ostarine mk-2866 are a good complement when expanded.
Fighting against millions of years of evolution, the body naturally wants to retain body fat and will first sacrifice muscle when it is starved of calories. By using Ostarine MK-2866, you’re less likely to lose quality muscle.
MK-2866 is not aromatized
MK-2866 is not aromatized or 5- -reduction. Why Sarms have become so popular. Without methylation, they do not burden the liver the way oral steroids do.
How does Ostarine MK-2866 work
The use of SARMS allows the synthesis of more protein, which can then be used to make muscle tissue. The use of Ostarine MK-2866 was very similar to the use of various steroids. However, there is no risk to the sex organs, including the prostate.
When SARM is used, muscle tissue produces anabolism. This is a fairly new treatment for serious health problems, including cancer and AIDS. It is often used by bodybuilders to give them more strength and muscle. It is also used to help them recover from injury or surgery. Many athletes take a low dose of 15 milligrams a day to reduce the risk of injury. Joint improvement can be found in about a week.
Using Ostarine MK-2866
There are various types of loops that one can choose to use Ostarine MK-2866. One of them is a weight gain cycle where they want to get lean muscle tissue. This causes them to gain weight, mainly muscle. They gained seven pounds, and you can see they took 25 milligrams a day for eight weeks. Daily dose should not exceed 40 mg. For best results, take it at the same time every day.
For a cycle called fat reduction, cutting calories and increasing exercise time can produce more muscle. Cutting without SARMS leads to decreased muscle mass, which is frustrating. This is due to decreased hormone levels and reduced metabolic rate. With Ostarine MK-2866, strength or muscle loss will not have to be concerned. For the cutting cycle, a dose of 15 to 20 mg daily for 6 to 8 weeks.
The nutritional value of this SARM is also very encouraging. Successful weight loss but the ability to maintain muscle growth is very important. With steroid use, it takes longer and longer to see an effect, but that was not the case with Austin MK-2866. There is also no risk of liver damage, a common side effect of steroid use. It also doesn’t cause blood pressure problems.
Taking MK-2866 has many advantages over steroids. They include:
no liver damage
does not change blood pressure
the results will be seen soon
helps prevent joint and bone problems caused by injuries
no risk of estrogen-associated side effects
no risk of water retention
provide nutritional value while cutting calories
At the end of the anabolic androgen cycle, the two most important things are:
1. Reactivate natural hormonal functions that have been suppressed during the cycle, primarily to bring testosterone back to normal levels.
2. In order to maintain the gains from the cycle, this is actively achieved when the first point is satisfied.
SERMs & AIs
In order to fully resume your natural test production, you need something to stimulate your pituitary gland to restart its regular activity. These drugs are divided into two families: SERM(selective estrogen receptor modulators) and AI(aromatase inhibitors). Common SERMs are Nolvadex (tamoxifen) and Clomid (clomiphene). The most commonly used AIs are: Femara, Arimidex, aromatin, and liquidex. Proviron is also an androgen with high e – resistance.
SERMs: these compounds bind to estrogen receptors and show good estrogen effects, which are associated with our recovery.
They are used in post-cycle therapy because they stimulate the pituitary gland to release more gonadotropins, promoting faster and higher release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Both hormones make the testes produce more sperm and testosterone, allowing the body to return to normal production levels.
AIs: they’re not like SERMs, they’re not estrogen. Their role is to prevent the conversion of androgens to estrogen. At the end of a cycle, the body no longer acquires exogenous hormones, and its natural hormone production is partially inhibited. Here are the risks of any estrogen-related side effects, such as increased fat and water, male breast development, low libido, and all the others mentioned earlier.
Using artificial intelligence to suppress estrogen receptors would suppress any temptation to question them. Therefore, they are often used over a cycle to prevent the aromatization of estrogen from being tested by aromatase.
When do I start my post-cycle therapy?
It depends on the cycle of medication use.
What is HCG and when is it used?
HCG, the human chorionic gonadotropin hormone, is recommended when your body’s sperm production needs rapid fixation. In fact, when boys are shrinking, they need nourishment.
Sometimes people find it useful to run at 500IU twice a week even in the last few weeks of a long cycle.
It should never be used alone without SERM, as it will replace the normal function of LH for a period of time and need to be supplemented again after the intake of HCG. That’s why I usually only advise when I have to.
Diet on the PCT
Don’t reduce calories when you think your body is in a highly anabolic state on PCT.
You have to maintain what you’re getting, and the PCT drugs themselves don’t work miracles, like the AAS, so keep them at high levels to maintain what you’re getting and change your diet with your goals.
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Primobolan is a unique compound that can be taken orally or injected. The only difference between the compounds was the attachment of the ester, the oral version using acetic acid and the injected version using enanthate. However, most people consider ketene to be a relatively mild compound, regardless of the administration method or ester administration. In most cases, users should not expect to get a lot of muscle mass from the drug, but should expect to gain lean muscle mass.
In some animal studies, it has been shown to have the potential to increase muscle size and strength. Anecdotal evidence from users, however, suggests that any large-scale gain from using the compound would not be too dramatic. However, it is considered a cutting medicine that is highly effective because it binds to androgen receptors in the body. Of course, the ability to bind to androgen receptors has been shown to promote fat burning in individuals. It is evident that this effect is very desirable in the “cutting” stage or simply limits the amount of fat that a person increases during the fat expansion phase.
Primobolan is not converted to estrogen, so the side effects of estrogen should not be associated with this compound. And, unlike other oral anabolic steroids, it is not a kind of steroid with 17 alkylation. This means it puts much less pressure on the liver than other oral steroids. However, the process by which oral methenone is made orally active, 1 alkylation and 17-esterification, does not protect it well the first time it passes through the liver. This requires that the oral version of metenolone be given at a higher dose than expected in the injected version. For this reason, it is often said that injectable drugs are much more effective at generating revenue.
Use and dosage of primobolan
As mentioned earlier, the difference in the dose required for oral and injectable metenolone is due to the action of the liver. In addition, due to the different ester/structure of the compounds, users use them with different frequencies. Methenolone oral forms should be administered at least once a day to maintain consistent blood levels of the drug, while the injected version of the drug is used once a week, because the two doses, however, will provide more consistent blood levels of the drug.
To make the oral combination effective, most men taking methadone need to take about 80 to 150 milligrams a day. Many users have reported anecdotally that they use the injected version and that it works well. Of course, many users will increase doses beyond these, and it’s not uncommon for doses to range from 600 milligrams to 800 milligrams or more of the compound to be injected weekly.
For women who are inexperienced with oral methadone, the daily dose is reportedly between 40 and 75 milligrams. For injectable drugs, 50 to 150 milligrams per week should result in a significant improvement in muscle mass and quality. At these doses, most female users rarely experience masculine effects. However, as the dose increases, these effects will be significantly more likely to increase.
As for the duration of methenolone use, there is nothing to worry about even if it is used for weeks, as the compound has no toxic problems and the side effects are relatively mild. It does not cause damage to the liver, kidneys or other organs. Of course, the natural testosterone secretion in the male is inhibited, but to restore the condition, it only requires a routine post-cycle treatment.
Female users report that methenolone alone is very effective, but some people superimpose it with other compounds to produce additional anabolic effects. Male users rarely use methenolone alone, choosing instead to combine it with any number of other potential compounds. This is mainly due to the mild nature of the drug. When used in combination with other drugs, it can offer some benefits, but taken alone may leave users dissatisfied.
The role of esters
One of the most misunderstood topics in the world of steroids is the role of esters — injectable esterifying steroids like cypionate testosterone, enanthate testosterone, and Sustanon. If you take a quick look at the Internet, you may find countless articles suggesting that one form of steroid is more effective than another. The debate on whether cypionate is better than enanthate, or Sustanon is better than all the other testosterone is, of course, fairly general. Such an argument is completely practical and groundless. In this report, we will study esters and their specific effects on steroids with authority.
What is ester and how does it work
I’m sure if you’re interested in anabolic steroids you’ll notice a lot of similarities on the labels. Let’s take testosterone for example. We can find compounds like cypionate, enanthate, propionate, phenylpropionate, isocaproate, decanoate. In all these cases, the maternal hormone is testosterone and is changed by the addition of esters (enanthate, propionate, etc.) to its structure. The next question is: what are the differences in the use of esterified testosterone for exercise?
An injectable anabolic/androgen esterification basically does one thing, it slows the release of the maternal steroid from the injection site. This is because esters significantly reduce the water solubility of steroids and increase their lipid solubility (fat). This causes the drug to form a deposit in the muscle tissue, and when a small amount is absorbed into the blood stream, the drug slowly enters the circulation. In general, the longer the ester chain, the lower the water solubility of the compound, and the longer the time required to reach the full cycle.
With the addition of esters, patients can see their doctors for injections infrequently once a month, rather than having to constantly readminister them for therapeutic effect. Obviously, without the use of esters, the injection of anabolic/androgen therapy would be much more difficult.
Esterification temporarily inactivates steroid molecules. Since the 17th beta site is blocked by a chain, it is unlikely to bind to the androgen receptor (which does not have any activity in the body). Therefore, in order for the compound to be active, the ester must first be removed. Once the compound is in the bloodstream, the esterase breaks down (hydrolyzes) the ester chain quickly, and the reaction occurs automatically. This will restore the necessary hydroxyl (OH) at the 17th beta site, allowing the drug to attach to the appropriate receptor. Only then
Steroids can affect skeletal muscle tissue. You can start to see why it doesn’t make sense to think that cypionate is more effective than enanthate, because all your muscles see is free testosterone, no matter what ester it’s developed with.
There are many different esters in anabolic/androgen steroids, but their action is essentially the same. Esters differ in their ability to reduce the water-solubility of steroids. For example, esters like propionate slow the release of steroids by a few days, while decanates take weeks.
The advent of esters is certainly a valuable advance in the field of anabolic steroids, but as you can clearly see, there is nothing magical about it. Esters act in a well understood and predictable manner and do not alter the activity of the parent steroid in any way other than delayed release. Although the allure of various steroid products, like cypionate testosterone, Sustanon, Omnadren and others, is certainly going to prompt interesting conversations, it’s actually just the wrong message that athletes are best to ignore. Testosterone is testosterone, and anyone who wants to tell you that this (or any) ester hormone is much better than the other should do more research and talk less.
Today I want to talk about some specific compounds, fast mass builders. What I mean is that drugs can with the fastest speed accumulation on users. Before I start, I want to say that these drugs increase mass, including water retention. These drugs are for people who want to get big and strong as soon as possible. However, you have to remember that gains the faster, the easier it is to lose them, so the appropriate follow-up work and initial yield are equally important.
If you want to increase it dramatically in a short period of time, then the drugs I’m going to talk about are for you.
Anadrol: this drug is known for its highly anabolic properties and for giving the user very plump muscles. It can quickly and effectively help users quickly gain quality and power. It’s an oral medication, usually 25 or 50 milligrams per pill, that’s easy to find. The normal dose is 50-150mg per day. Since it is an oral steroid, it is not recommended for beginners for more than 4 weeks and for advanced users for more than 6 weeks. It should also be noted that counterfeit versions of the drug are not commonly found.
Dbol: it is so well known that you hear about it from people who know nothing about steroids, or mention it in jokes about someone taking steroids. This medicine is readily available and widely used. Almost anyone who has ever used d-bol on steroids and is new to it tends to want to run it as a cycle. The rapid increase in quality and strength of the drug is often compared to Anadrol. Many people believe that d-bol is stronger than mg-mg because the dose of d-bol is usually no more than 30 or 40mg, and similar results can be seen in anadrol. As I mentioned, the effects of these drugs are similar to Anadrol, but most people don’t think they are as dramatic. In my opinion, it’s more of a personal choice. D-bol also seems to have less side effects, making the user feel better when using it. It creates a feeling of happiness. The drug is most commonly taken as an oral tablet, but can also be used as an injection. It is recommended to take 30 to 50 milligrams daily. Counterfeit drugs are also less common. In general, I think d-bol is a better choice for users who don’t like side effects.
Testosterone: testosterone is a basic substance but is listed as a rapid weight gain agent. Because you have the choice of esters. With suspension or propionate, testosterone will peak faster in your blood and start gaining weight faster. The Suspension is well known, so this is the medicine I’m talking about. Users reported a rapid increase in mass and strength when using suspension, but they also reported that side effects were more dramatic than when using long esters. So while users can gain weight quickly, they can also experience side effects such as water retention, acne and possibly elevated blood pressure. It is the half-life of the ester and the rapid action. So it has to be injected regularly. Two injections a day are said to be best, but for those who can take it, even four injections a day bring higher blood levels. It is also important to note that many users report that the suspension can cause pain at the injection site and even make it difficult to pass the needle. That’s because it’s water-based, and it has some particles in it. The pain is usually caused by your muscles absorbing water faster than the hormone particles, leaving behind crystals of the hormone in the area of the stimulus. This can be very uncomfortable for some people. Therefore, it is important to know your pain tolerance and check the pain level of certain brands before you try to use the drug. Testosterone suspensions come in a variety of brands, typically 50mg or 100mg/ml. Injection type, generally 50-150mg/day.
Deca (Nandrolone): this is probably the most famous steroid after d-bol. It doesn’t cause many side effects and can lead to weight gain at the right time. In general, it takes at least 4 weeks for normal deca to peak in the blood, so it should not be included in this topic. However, with the debut of NPP (nandrolone phenylpropionate), you can now peak off the charts in less than a week. For some reason, people who take this fast-acting drug retain less water in their bodies, so it may not make you swell as much as a regular deca. NPP is growing in popularity because many people like to use deca, but don’t want to wait too long or let it swell. It is injectable, usually in doses of 50-100 mg /day.
I feel like I’ve forgotten one person, but those are the main ones I want to mention today. I know a lot of people who want to gain a lot of weight quickly. If that’s what you want, then these pills are for you. However, you have to remember something. These drugs can cause a lot of water retention, so be aware of this.
Steroids can strengthen muscles. If your goal is to lose excess weight and improve your fitness, there are many products for weight loss in addition to making significant changes to your diet and exercise habits. Consider using steroids when you’ve been exercising for at least two years or more. You won’t waste your hard-earned money and what you gain will be pure muscle. Below are steroids which are suitable for women.
Anavar is one of the most benign anabolics for women and has low androgen activity. It is known to increase strength and build quality muscles. At a low dose of 5 mg per day, most women did not see any adverse side effects. A typical cycle should start at 6-8 weeks.
Primobolan is another mild steroid. It is not converted to estrogen, which is an advantage of this, if you are concerned about water retention. Most women respond well to doses of 50-100 milligrams per week. A typical run time is 8-10 weeks. Primobolan slowly and steadily increases strength and builds quality muscle.
Winstrol can be taken in oral or injected form. Winstrol should not be used with a beginner’s cycle. When your eating habits are good, this is a good drug to use during your weight loss cycle. Winstrol increases quality and gains amazing power. Women typically take 5-10 milligrams a day. Keeping the dose low will reduce the chance of unwanted side effects. It is generally advisable to separate the doses during the day to maintain a balanced blood level. At the time of injection, 25 mg is usually a normal dose every 3 or 4 days. This cycle runs for 8 weeks. Remember to eat the milk thistle because this steroid puts stress on the liver.
Deca is popular among women. Although it is only mildly androgenic, it can sometimes be expected to be masculine. Again, low doses are key. Deca is not a quick builder of muscle, but a slow, gradual gainer of muscle and strength. Women should start with about 50 milligrams a week.
If you need to be exposed to Testosterone, then Testosterone should be your choice. Just because it gets in and out of your system quickly. Therefore, if any unwanted edges appear, all you need to do is stop using them and they will be removed from your system very quickly. Had better be dispersive inject, inject 25 to 50 milligram every time commonly, every 5 to 7 days inject. This cycle should be longer than 8 weeks. It is important to closely monitor the use of Testosterone Propionate.
Women don’t need to reduce the dose of steroids every day during the cycle. Once the loop ends, stop using it. For women, many of the side effects of anabolic steroids are irreversible. Before choosing a drug, make sure you have studied and read a lot about steroids.
Know about 17-alkylated steroids
You may have heard that 17-alkylated steroids are harder for the liver to metabolize and therefore require more effort to break them down. All 17-alkylated steroids are toxic to the liver. Non-17-alkylated steroids are not toxic to the liver. All these views are not true.
17-alkylated steroids are known to be toxic to the liver. How toxic depends on who you believe in. The media and many doctors think they are deadly, while many people online think they are actually harmless. There seems to be a lot of confusion on this topic, even among people who know a lot about steroids. The fact is that it depends how you use steroid and the actual instructions you get. Dose and duration are the main fators when it comes to steroid use. Hopefully we can dispel some rumors about how toxic substances are and how to reduce or prevent toxicity.
Toxic effect of steroid
What are the toxic effects of oral steroids? By far the most common toxicity is intrahepatic cholestasis. Generally, cholestasis is any condition in which bile ceases to flow, and oral allergy occurs in the liver. Normally, bile is released into the small intestine and its main function is to help absorb fats and lipids. This prevents bile salts from being released into the bile ducts, leading to the buildup of liver cells. This accumulation may be toxic to hepatocytes over time. Jaundice is the yellowing of the skin and eyes and is associated with cholestasis. This is because bilirubin (a product of the breakdown of red blood cells) is usually excreted through the bile. During cholestasis, the skin and eyes gradually turn yellow, a sign that something bad is happening. Jaundice is rare except in newborns, and if you notice these symptoms, you should seek professional health care. The type of cholestasis usually seen in oral steroids is clinically classified as “mild cholestasis” because there is no inflammation associated with cholestasis. This type of cholestasis is completely reversible when the pathogenic agent is stopped.
In addition to cholestasis, other reported toxic effects are cirrhosis of the liver and hepatic adenoma. Liver disease is a cavity in the liver that is filled with blood. This is a rare condition in which the theory is that cirrhosis of the liver is caused by blocked outflow of hepatic blood at the junction of the sinus vein and the lobular central vein. What causes this? It is thought to be associated with cholestasis, which causes the growth (swelling) of liver cells. In patients with AAS, obstruction may be due to prolapse of hepatocyte proliferation into the hepatic vein wall. This is good news because it means that if cholestasis can be prevented, cirrhosis can also be prevented.
Hepatic adenoma has been mentioned many times in the literature as a possible effect of oral steroids. This is extremely rare and appears to occur only after months or years of continuous use. It may also be associated with prolonged cholestasis. In my opinion, don’t worry unless someone in your family has contracted cholestasis from oral steroids (including birth control pills). The real focus of safety should be preventing cholestasis.
Function of Liver
The liver has many important functions in the body, but these include drug metabolism and excretion, and the secretion of bile salts and bicarbonates for digestion.
For 17-alkylated steroids, the conversion from 17-hydroxyl to 17-ketone steroids is prevented. That’s the key. The main difference between 17-aa and regular steroids is that the former retains a free 17-hydroxyl group in the liver, while the latter does not. The reason 17-aa is toxic is that the free hydroxyl group can combine with glucuronic acid to form d-ring 17-glucuronolactone. It is not the 17-aa steroid that is toxic to the liver, but the 17-glucan metabolite. It’s not that these steroids are harder to metabolize, it’s the way they’re metabolized that makes them toxic.