IGF-1 VS.  IGF-1 LR3

What is IGF-1

Insulin-like growth factor-1, commonly known as IGF-1, is a polypeptide hormone belonging to the growth factor hormone family. This is a naturally occurring hormone that occurs primarily in the liver and to some extent in surrounding tissues in all humans. However, synthetic versions do exist and are produced using recombinant DNA technology.

IGF-1 is a highly anabolic hormone that affects many areas of the body. It also has an important relationship with human growth hormone (HGH), and its structure is similar to insulin. There are several synthetic IGF-1 products on the market, but perhaps the most famous is Tercia INC.

IGF-1 is mainly used to treat IGF-1 defects. However, it is also used in patients who do not respond to HGH. Then there’s the performance, and in recent years IGF-1has become an important hormone in this field. It is a powerful anabolism that will carry strong recovery properties and has become a favorite of many bodybuilding circles.


Growth factors like IGF play an important role during childhood, especially during adolescence. IGF is responsible for natural muscle growth that occurs during puberty, as well as other functions, such as increasing glucose transport, increasing protein synthesis, increasing RNA synthesis, increasing amino acid transport to cells, and reducing protein degradation.

However, there are different forms of IGF, such as IGF-1 and IGF-1 LR3, with different potency and function.

IGF-1 LR3, which is a form of IGF that has been altered by chemical changes in amino acids. It is composed of 83 amino acids, one of which, Arg(R), is transposed to Glu(E) and is located at position 3, hence the name R3. The change allows it to avoid binding to proteins in the body, extending its half-life.

LR3 is stronger than conventional IGF-1 due to reduced binding of IGF-1 to IGF-binding protein in long R3. Its main purpose is to improve the biological activity of IGF.

In essence, when IGF-1 LR3 is active in vivo, it performs different functions in different types of tissues. In muscle tissue, for example, it makes muscles more sensitive to the effects of insulin, such as reducing fat storage. But while IGF-1 LR3 helps reduce fat, people who use it gain weight as a result of pure muscle weight gain.

IGF 1 dosage

IGF-1 dosage and a specific protocol of use are controversial topics in the field of medicine and performance enhancement. In the treatment environment, the IGF-1 dose is usually in the range of 40-80mcg and can be given 1-2 times a day. There is no doubt that this is a very large dose, and when we think about hypoglycemia, it can be very difficult to control. Most doctors won’t start an individual above 40 micrograms and will closely monitor levels. The dosage may be increased by 20 micrograms if necessary, but for whatever reason, it will not exceed 120 micrograms, as this will be extremely difficult or even impossible to control hypoglycemia.

50-60 MCG per day is very common in performance Settings, but it is often redundant. If a person eats enough food and USES anabolic steroids, it doesn’t take a lot of IGF-1 to have a significant effect. Add your IGF-1 recommended use of growth hormone and the results will be remarkable. Most people can easily start with 15mcg once a day and increase the dose slightly when needed, but this is a good starting point and will be all the IGF-1 many people need.

And then the total utility. In the performance Settings, IGF-1 will be used for 2-4 weeks and will not be reused for 2-4 weeks. As briefly discussed earlier, many people will continue to use IGF-1 beyond the anabolic steroid cycle, entering the transition phase of maintaining low doses of testosterone and growth hormone. However, this is something only core and experienced hormone users do. If you are getting out of the cycle and into the PCT phase, IGF-1 use is not recommended because promoting excess body fat would be a huge risk.

IGF-1 LR3 dosage

50-100mcg of IGF-1 Lr3 divided into 1-2 bilateral administrations into 2-5 different areas of the muscles approximately 5-7 days a week – intramuscular injections.

IGF-1 functions and features

IGF-1 is a protein hormone composed of 70 amino acids. Synthetic or naturally occurring sequences are identical; It makes no difference. As a functional hormone, IGF-1 supports growth mainly by enhancing amino acids, glucose, and fatty acids. Because it is closely related to insulin, it can also affect your blood sugar levels. Using IGF-1 may significantly reduce blood sugar, leading to hypoglycemia. Due to the enhancement of fatty acids, this further creates the ability to promote body fat, which is undoubtedly a potential disadvantage of using. However, it is worth having a good diet and lifestyle plan when supplementing exogenous IGF-1.

IGF-1 has been shown to significantly increase the number of skeletal muscle cells, thereby promoting the growth of lean muscle tissue. This is achieved by activating the phosphatidylinositol 3 kinase (PI3K) -Akt pathway. Not only does it promote muscle growth, but in this way, it also promotes bone growth and, to a certain extent, the growth of our internal organs.

IGF-1 is also closely related to human growth hormone (HGH), another powerful hormone naturally produced by humans. Like IGF-1, HGH is anabolic, and IGF-1plays a significant role in the anabolism provided by HGH. This includes two main characteristics, usually associated with anabolic metabolism, nitrogen maintenance, and protein synthesis. Since all lean tissues are made up of about 16 percent nitrogen, increasing nitrogen retention is important. When nitrogen storage drops, this may cause an individual to enter a catabolic (muscular atrophy) state. On the contrary, the more nitrogen we retain, the stronger our anabolic capacity. We build and support more lean organizations. As for protein synthesis, this represents the rate at which cells produce proteins, which represent the major components of lean muscle tissue. It’s not hard to see how boosting protein synthesis can be beneficial. Not only will this allow you to build and support more lean organizations, but it will also play an integral role in the recovery process, which is where real progress is made. This close association between IGF-1and HGH is also responsible for the proliferation of muscle cells and the promotion of new muscle fiber growth. With IGF-1, you will have more muscle cells (muscle cell proliferation) and muscle fibers (mitosis).

While IGF-1’s function and properties in terms of anabolic capacity are enormous, they are controlled by the amount of protein provided to muscle cells. Without sufficient protein, the supplementation of exogenous IGF-1 will be of very little value.

IGF-1 also has important features around healing and recovery; In fact, they are very strong. This is particularly true when we consider the role of hormones in connective tissue formation. IGF-1 also improves the function of collagen, which is found in all connective tissue in the body. Improvements in collagen function will make bones stronger and muscles stronger for proper exercise. It can even affect the skin and blood vessels in a positive way. From here, IGF-1 will also promote cartilage repair and promote bone density, making it an excellent hormone for recovery and repair.

One final note on IGF-1 properties: this hormone is considered a neuroprotectant that may improve mental function. When dementia is a problem, this factor can be very beneficial for the elderly. However, further research is needed to fully understand these effects, but they seem promising.

IGF-1 effects

The role of IGF-1 is usually best suited to promote off-season weight and any athlete’s physical recovery. Few people use this hormone during weight loss cycles because it negatively affects an individual’s metabolic rate. That’s the last thing you want when you’re on a diet, but we can make an exception. Some competitive bodybuilders are able to use the IGF-1 in their race preparation and stay lean while also maintaining more lean quality. It takes years of experience to do this, not just to understand hormones thoroughly, but to understand how they affect you as an individual.

Many people use anabolic steroids during their anabolic steroid treatment, which only increases the rate and amount of lean tissue formation. More advanced bodybuilders will use it during the bridge cycle. Bridge cycle is the period of time between the anabolic steroid cycle or the complete bulking cycle. In this case, the patient will continue to receive a maintenance dose of testosterone and IGF-1 will be added. Many of those who do so are also using HGH, just continuing from the cycle they just ended to the bridge they just started. It is generally recommended to use HGH regardless of the specific time you use it, during cycling or as a bridge. IGF-1, although potent anabolism also has the ability to promote excess fat storage. Maintaining appropriate body fat levels during off-season weight gain is difficult enough on its own, and only the use of IGF-1 complicates the situation. However, when growth hormone is included, the metabolic boost it provides should be sufficient to control the disease. In addition, the synergy between the two hormones is significant.

The ultimate effect of IGF-1 revolves around recovery. This hormone promotes full recovery from training and strenuous exercise, but it doesn’t end there. IGF-1actually has a direct therapeutic function, not masked like a painkiller, but really therapeutic. The use of IGF-1 can significantly reduce the total time for joint injury healing. It has even been shown to significantly help heal tendons and ligaments. Because all of these areas of the body are hit by most athletes, the IGF-1becomes extremely valuable.