Category: steroid ester
If you don’t know steroids, don’t use them lightly. Athletes use steroids to achieve their ideal physique, but it’s not a one-size-fits-all experience. You may get some great muscle for a while, but it’s all in vain if you don’t maintain it during the off-season.
What is a typical off-season cycle like for some of the larger competitive bodybuilders (heavyweight or super-heavyweight)?
Admittedly, everyone’s situation is different, but once a certain level of development is reached, some constants emerge.
Testosterone is the basis of most big men — because we’re talking about the off-season, usually enanthate or cypionate — by about 1,200 to 2,000 milligrams a week. Testosterone is any cycle of bread and butter.
Then there are the anabolic drugs, with most large people taking 600-1000 milligrams of Boldenone or Deca Durabolin (Nandrolone) per week. Sometimes they use Primobolan or Trenbolone, but that’s not common in the offseason; Most people stick to Boldenone and Nandrolone Decanoate, alternating between the two drugs for 8-10 weeks at a time.
After that, you look at the daily dose of growth hormone (4-10 international units per day). Personally, I don’t think it’s necessary to walk higher, although some people will run more if they can afford it.
Most people (but not all) also use insulin, usually 10-20 units per day of humulin-r or Humalog. Again, this is something that some people will use more of, but I don’t think it’s wise from a health standpoint – even from a growth standpoint.
After that, some people might take strange oral steroids from time to time, like Dianabol or Anadrol every few months or so for four weeks, but that’s not really necessary — some people just like a quick boost of strength and bloating.
Most people also take some form of the anti-estrogen drugs, such as Arimidex, throughout the year, about one milligram every other day.
The role of esters
One of the most misunderstood topics in the world of steroids is the role of esters — injectable esterifying steroids like cypionate testosterone, enanthate testosterone, and Sustanon. If you take a quick look at the Internet, you may find countless articles suggesting that one form of steroid is more effective than another. The debate on whether cypionate is better than enanthate, or Sustanon is better than all the other testosterone is, of course, fairly general. Such an argument is completely practical and groundless. In this report, we will study esters and their specific effects on steroids with authority.
What is ester and how does it work
I’m sure if you’re interested in anabolic steroids you’ll notice a lot of similarities on the labels. Let’s take testosterone for example. We can find compounds like cypionate, enanthate, propionate, phenylpropionate, isocaproate, decanoate. In all these cases, the maternal hormone is testosterone and is changed by the addition of esters (enanthate, propionate, etc.) to its structure. The next question is: what are the differences in the use of esterified testosterone for exercise?
An injectable anabolic/androgen esterification basically does one thing, it slows the release of the maternal steroid from the injection site. This is because esters significantly reduce the water solubility of steroids and increase their lipid solubility (fat). This causes the drug to form a deposit in the muscle tissue, and when a small amount is absorbed into the blood stream, the drug slowly enters the circulation. In general, the longer the ester chain, the lower the water solubility of the compound, and the longer the time required to reach the full cycle.
With the addition of esters, patients can see their doctors for injections infrequently once a month, rather than having to constantly readminister them for therapeutic effect. Obviously, without the use of esters, the injection of anabolic/androgen therapy would be much more difficult.
Esterification temporarily inactivates steroid molecules. Since the 17th beta site is blocked by a chain, it is unlikely to bind to the androgen receptor (which does not have any activity in the body). Therefore, in order for the compound to be active, the ester must first be removed. Once the compound is in the bloodstream, the esterase breaks down (hydrolyzes) the ester chain quickly, and the reaction occurs automatically. This will restore the necessary hydroxyl (OH) at the 17th beta site, allowing the drug to attach to the appropriate receptor. Only then
Steroids can affect skeletal muscle tissue. You can start to see why it doesn’t make sense to think that cypionate is more effective than enanthate, because all your muscles see is free testosterone, no matter what ester it’s developed with.
There are many different esters in anabolic/androgen steroids, but their action is essentially the same. Esters differ in their ability to reduce the water-solubility of steroids. For example, esters like propionate slow the release of steroids by a few days, while decanates take weeks.
The advent of esters is certainly a valuable advance in the field of anabolic steroids, but as you can clearly see, there is nothing magical about it. Esters act in a well understood and predictable manner and do not alter the activity of the parent steroid in any way other than delayed release. Although the allure of various steroid products, like cypionate testosterone, Sustanon, Omnadren and others, is certainly going to prompt interesting conversations, it’s actually just the wrong message that athletes are best to ignore. Testosterone is testosterone, and anyone who wants to tell you that this (or any) ester hormone is much better than the other should do more research and talk less.