Nandrolone Phenylpropionate is an injectable form of the anabolic steroid Nandrolone. The properties of this drug are very similar to those of Nandrolone Decanoate. The main difference between the two preparations is the rate at which nandrolone is released into the bloodstream. Nandrolone Decanoate provides about three weeks of Nandrolone release at the injection site, while Nandrolone Phenylpropionate provides only one week. So Nandrolone Decanoate can be given clinically every two or three weeks, while Nandrolone Phenylpropionate is given clinically once a week. On the other hand, the two drugs are actually interchangeable. Like Nandrolone Decanoate, drugs such as Phenylpropionate, which enable athletes and bodybuilders to increase muscle strength and lean muscle mass, are valuable and do not have significant estrogen or androgen side effects.
Nandrolone Phenylpropionate first appeared in 1957. It soon became a prescription drug marketed by the international pharmaceutical giant Organon (now Merck/MSD) under the brand name Nandrolone Phenylpropionate. When first introduced in the United States, Nandrolone Phenylpropionate was used for the retention of sperm quality before and after surgery, osteoporosis, advanced breast cancer, weight loss due to convalescence or disease, geriatric diseases (general weakness and weakness), burns, severe trauma, ulcers, anemia, and developmental retardation in children. In the 1970s, the FDA began to modify the use of the drug, and its use quickly declined significantly. After a while, the drug was used primarily to treat advanced metastatic breast cancer and as an adjunct therapy for postmenopausal osteoporosis in the elderly.
Nandrolone Phenylpropionate has been Organon’s focus for less than a decade. When Nandrolone Decanoate was introduced in the 1960s, drugs with short-term effects, such as Phenylpropionate, were still available but began to decline. At the time, Nandrolone Phenylpropionate had not been abandoned by Organon, in part because some countries had slightly different therapeutic USES and thus remained profitable for some time. As the anabolic steroid market continued to grow in the 1970s and 1980s, it caught the attention of other drug manufacturers, and many drug companies have begun to make their own Nandrolone Phenylpropionate. Today, however, the drug is almost non-existent. The current owners of Organon (Merck/MSD) will sell Nandrolone Phenylpropionate, which is nearing the end of production.
Nandrolone Phenylpropionate is circulating in some human drug markets. The composition and dosage may vary from country to country and manufacturer, but usually contains 25 mg/mL or 50 mg/mL of steroids dissolved in oil.
Nandrolone Phenylpropionate is a modified form of Nandrolone in which a carboxylate (Phenylpropionate) has been attached to a 17-beta-hydroxyl group. Esterified steroids have less polarity than free steroids and are absorbed more slowly in the injection area. Once in the blood, the ester is removed to produce a free (active) nandrolone. Esterified steroids are designed to extend the therapeutic window after administration, allowing less frequent injections than free (unesterified) steroids. Nandrolone Phenylpropionate peaked at release 24 to 48 hours after deep intramuscular injection and dropped to near baseline within a week.
Side effects (estrogen)
Nandrolone’s estrogen conversion is low, estimated at about 20 percent of testosterone. This is because although the liver converts Nandrolone to estradiol, the estrogen-related side effects of nandrolone are much lower in other, more active, steroid-aromatizing sites, such as adipose tissue. However, elevated estrogen levels at high doses are still noticeable and can cause side effects such as increased hydration, body fat, and breast development in men. Anti-estrogens such as clomiphene or tamoxifen may be necessary to prevent the occurrence of estrogenic side effects. People can also use aromatase inhibitors, such as anastrozole, which control estrogen more effectively by preventing its synthesis. However, compared to anti-estrogen, aromatase inhibitors can be quite expensive and may have negative effects on blood lipids.
It is noteworthy that nandrolone has some progesterone activity in the body. Although progesterone is a c-19 steroid, the removal of this group produces a hormone with a greater binding affinity for its corresponding receptor. Because of this feature, many no-19-anabolic steroids have shown some affinity for progesterone receptors. Progesterone-related side effects are similar to estrogen, including negative feedback inhibition of testosterone and increased fat storage. Progesterone also increases estrogen’s role in stimulating breast tissue growth. There seems to be a strong synergy between the two hormones, so even without excessive estrogen levels, male breast development may even occur under the influence of progesterone. The use of anti-estrogen, which inhibits estrogen, is usually sufficient to reduce the risk of breast dysplasia in men caused by nandrolone.
Side effects (androgen)
Although classified as anabolic steroids, the substance may still have androgenic side effects, especially at higher doses. These side effects may include oily skin, acne, and episodes of body/facial hair growth. Anabolic/androgen steroids may also aggravate male hair loss. Women are also warned of the potential pathogenic effects of anabolic/androgen steroids. These may include deepening of the voice, irregular periods, changes in skin texture, facial hair growth and clitoral enlargement. Norone is a steroid with relatively low androgen activity relative to its tissue-building effects, so the threshold for androgen side effects is quite high compared to androgen drugs such as testosterone, methyltestosterone. It’s also important to point out that because of its mild androgen properties and ability to suppress endogenous testosterone, nandrolone tends to interfere with sexual desire in males when not using another androgen.
Note that in androgen responsive target tissues such as skin, scalp, and prostate, the relative masculinity of nandrolone is reduced by reduction to DHN. 5- alpha reductase is the main cause of this metabolism. Concurrent use of 5-alpha reductase inhibitors such as finasteride or rasterize interfered with the site-specific effects of nandrolone significantly increasing its tendency to produce androgenic side effects. If low androgen sex is required, use of nandrolone should avoid reductase inhibitors.
Side effects (hepatotoxicity)
Norone is not c-17 alpha alkylation and does not have hepatotoxic effects. So hepatotoxicity is unlikely.
Side effects (cardiovascular)
Anabolic/androgen steroids may have harmful effects on serum cholesterol. This includes the tendency to lower HDL (good) cholesterol levels and increase LDL (bad) cholesterol levels, which may convert HDL to LDL, leading to a greater risk of atherosclerosis. The relative effects of anabolic/androgen steroids on serum lipids depend on the dose, the method of administration (oral versus injection), the type of steroid (aromatized or not), and the level of resistance to liver metabolism. Weekly administration of 600mg Deca for 10 weeks showed a 26% reduction in HDL cholesterol levels. This inhibitory effect is slightly higher than that reported by using the same dose of actor Enanthate, which is consistent with earlier research results that Deca has a stronger negative effect on HDL/LDL ratio compared with actor Propionate. The effect of nandrolone on serum lipids was significantly weaker than that of c-17 alpha alkylated. Anabolic/androgen steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and lead to left ventricular hypertrophy, which may increase the risk of cardiovascular disease and myocardial infarction.
To help reduce cardiovascular stress, it is recommended to maintain an active cardiovascular exercise program and to consistently minimize saturated fat, cholesterol, and simple carbohydrates throughout the use of AAS. Also suggested supplementation with fish oil (4 grams per day) and natural cholesterol/antioxidant formula such as Lipid Stabil or products with a similar component.
Side effects (testosterone suppression) :
All anabolic/androgen steroids are expected to inhibit endogenous testosterone production when taken at doses sufficient to promote muscle gain. Studies on 100mg Nandrolone Phenylpropionate have shown that serum testosterone can be rapidly suppressed by a single injection. Testosterone levels dropped to 30% of their initial level on day 3 and remained there for about 13 days. Frequent use can significantly prolong the endogenous hormone recovery window. It is thought that the progestational activity of norone significantly facilitates the inhibition of testosterone synthesis during treatment. Without intervention from testosterone stimulants, testosterone levels should return to normal within 2-6 months of drug disruption. Note that hypogonadism may be secondary to steroid abuse, requiring medical intervention.
In addition to these side effects, for a more detailed discussion of potential side effects, see the steroid side effects section of this book.
For general anabolic effects, early prescribing guidelines recommend a dose of 25 to 50 mg per week for 12 weeks. Doses commonly used for physical or performance enhancement purposes range from 200 to 400mg per week and are administered over a period of 8 to 12 weeks. This level is enough for most users to see a measurable gain in lean muscle mass and strength. Note that because of the rapidity of phenylpropionate, the weekly dose is usually divided into two doses.
For general anabolic effects, early prescribing guidelines recommend a dose of 25 to 50 mg per week for 12 weeks. When used for physical or performance enhancement purposes, a dose of 50mg per week (single weekly injection) is the most common, lasting 4 to 6 weeks. Higher doses or longer duration of use are not recommended due to potential androgen side effects. Although only mildly androgenic, women occasionally face viral symptoms when taking the compound. If side effects occur, immediately discontinue phenylpropionate to prevent permanent side effects.