Arimidex (anastrozole) was patented in 1987 and approved for medical use in 1995. Anastrozole can be used as a generic drug. Arimidex (anastrozole) was the first selective aromatase inhibitor for bodybuilding and remains the most popular estrogen-control drug. It is usually taken orally in tablet and liquid form. The dose is usually 0.25,0.5 or 1.0mg per dose at a frequency of once daily or once every two days.
Estradiol, the most potent form of estrogen, is produced in the body through the aromatization of testosterone. This process occurs through aromatase. Because men need a certain level of estradiol, testosterone needs to be converted to estradiol. However, in both cases, effective aromatase inhibition can provide important benefits.
First, conversion to estradiol becomes excessive when the anabolic steroid cycle leads to very aromas steroid levels and when aromatase cannot be controlled. The resulting high estradiol may cause breast, water retention, depression and/or decreased libido in men and women. This can also make it difficult to maintain a lean state.
Second, estradiol levels in some men were elevated even without anabolic steroid circulation. This will have the effect of reducing the production of natural testosterone and may cause these adverse side effects. Arimidex is perfect for solving any problem. With the right dosage, free estradiol levels can be brought to the desired range with considerable precision. When not using anabolic steroids, I recommend about 20-29 pg/mL for most men to maximize mood, performance, libido, and long-term health, and to provide excellent benefits for the production of natural testosterone. Levels can be allowed to rise a little during the steroid cycle because high androgen levels are used to counteract the adverse effects of estradiol. Sometimes slightly higher estradiol is needed to protect the walls of our blood vessels and keep them softened. Nevertheless, I suggest that estradiol levels should be kept at no more than about 40 pg/mL even during the intense anabolic cycle. Aromatase inhibitors, such as Arimidex, are usually required if aromas steroids are added.
Most medical studies on the effects of Arimidex on men have used it at 1mg/day, a dose that appears to be at its best on the effects of estradiol levels. However, real-world applications for circulating steroids or optimizing hormone levels generally use lower doses, ranging from 0.25mg every other day to about 0.5mg per day. It is generally recommended to use 0.5 mg every other day as the starting point of the steroid cycle, or half of the optimal hormone level if there is a high estrogen problem.
Excess Arimidex results in abnormally low estradiol levels and typical side effects of joint pain decreased libido, and/or gastrointestinal distress. The first two are directly caused by low estradiol. If you encounter these effects, reduce the dose. The effect on the gastrointestinal tract seems to be a side effect of Arimidex itself, but fortunately only affects a few people. If this effect occurs, I recommend letrozole as an alternative to aromatase inhibitors.
Anastrozole has a half-life of about two days. So it should be used two days before other drugs, rather than waiting weeks for them to pile up. This is done by using the first does not only as a regular dose but also for the next two days. For example, if you plan to take 0.5 mg every other day, that would be an extra 0.5 mg. Therefore, the preloading dose is 1.0 mg. This will only be done on the first day of use. With this approach, the appropriate effect can be achieved almost immediately.
The controversial pairing is the use of Arimidex for PCTS. Some argue that driving estradiol levels abnormally low in PCTS stimulates testosterone production; I’m a strong advocate of SERM like Nolvadex or Clomid because it completely blocks the aromatase function and turns testosterone into estradiol, which needs to be restored to normal levels. However, if a person needs Arimidex even aperiodically because of its naturally high aromatization, then his aperiodic dose can also be used during the PCT.
Compared to letrozole, Arimidex was the best. Both drugs are effective in aromatase control. The choice between them depends entirely on personal preference, experience, and availability.