Testosterone undecanoate is hepatotoxic because it is a 17 alkylated steroid. Testosterone undecanoate has eliminated the need to change the compound, so it can survive its first passage through the liver and remain effective by skipping this step. By delivering it to the liver for the first time, this negates the need to change the compound to ensure it remains active, and thus does not put additional strain on the liver.
The amount of drugs that enter a person’s bloodstream depends on the ability of the person’s lymphatic system to absorb the compound. This varies greatly among different users. For this reason, it is difficult to say exactly how many compounds have entered a person’s body without taking a blood sample at a specific time. For most users, this will be a guessing game about how much testosterone undecanoate is actually absorbed and how “active” it is. This is one of the reasons it is not a complete replacement for injectable compounds.
As with other forms of testosterone, the doses given to men and women vary widely. In the case of testosterone undecanoate, it is usually the general characteristics of the price and/or compound that limit the dosage the user is willing to use.
Like other testosterone compounds, it can accumulate with most other compounds. However, due to the unreliable absorption rate, users should be cautious when using anabolic steroids with other drugs. If the absorption of testosterone undecanoate is not very effective, this may result in low testosterone levels as the user inhibits natural testosterone production. This can lead to sexual dysfunction and/or decreased libido in some people, depending on the compounds they use. In most cases, users are advised to take the dosage with meals, as this will aid in lymphatic absorption.
In addition to the common side effects associated with the use of any type of testosterone compound, there are no other specific side effects associated with testosterone undecanoate. The drug appears to respond in the same way as other drugs, affecting cholesterol, the hypothalamic-pituitary-testicular axis and other bodily functions. Some studies seem to suggest that the compound can actually improve a user’s blood pressure without much effect on the prostate. However, like most studies, these conclusions should not be taken as absolute.
Because testosterone undecanoate bypasses the liver completely, there is no problem with liver hypoxia. Also, because testosterone is less active for longer, women who try it may find it a more attractive option. If serious side effects occur, the medication must be discontinued immediately.