Month: July 2017


China Supplier Sale Boldenone Acetate Raw Powders Wtih Delivery Safety Ensure


Boldenone acetate is but one form of Boldenone. It’s an anabolic androgenic anabolic steroid modified by the acetate ester. Esters influence any drug’s absorption price and half-life or the period of time the medication gives the intended perform or perhaps activity within the body. Use trends, serving and also possible unwanted effects should invariably be very carefully reviewed with a muscle builder prior to with all the anabolic steroid. This can be so as not only to achieve ideal outcomes, yet to avoid uncomfortable or undesirable side effects.

Boldenone acetate is among the common forms of Boldenone bottom medication utilized by body builders for faster muscles benefits along with other benefits. While not the most frequent kind of Boldenone (Boldenone Undecylenate Equipoise, is regarded as the common), it’s easily available from online as well as undercover resources. Boldenone acetate, such as other forms with the bottom anabolic steroid, are thought mainly because vet quality anabolic steroids that were by no means designed for use on human beings. The medication is used mostly on race horses as well as other big creatures, and has previous use in horse race situations.

A potential user regarding Boldenone acetate steroids will come across numerous suggestions in regards to dosage and cycling. Actually, serving recommendations vary from 3 hundred milligram weekly to be able to approximately Seven-hundred mg, and quite often more. Shots are often needed every second day or perhaps each 3rd day. Regarding ideal benefits, it should be found in any routine that lasts at least 6 weeks. Several keep going longer. The Boldenone acetate routine can be done alone or perhaps loaded with other types of testo-sterone (enanthate, cypionate, and so on.) depending on personal preferences as well as encounter.

To be able to understand how this kind of acetate version of boldenone is different from the conventional a single using the undecylenate ester, we have to first understand what esters and 50 percent lifestyles imply. The most used sort of Equipoise (EQ) may be the undecylenate version with a half duration of 14 days, even though the acetate ester’s 50 percent life’s simply 72 hours. Obviously, this can be a huge variation.

Contrary to popular belief marketed of all steroid discussion boards, half life does not refer to the length of time an ingredient will be mixed up in entire body, and it actually will take several 50 percent lifestyles before the compound’s esters completely clear one’s body. Moreover, this can be determined by the length of time you have due to the substance in order to ‘build upwards,A given that a couple of shots is not the same as 12 injections. After the compound gets to top levels in your body, it may need around 3-4 half lives because of it to eradicate generally. Consequently, with all the “Undecylenate” ester of Equipoise, it may need 5-6 days to depart the machine when compared with 1-2 months with the acetate edition.

Therefore, half life simply refers back to the time frame required for the particular power the actual medication to be lowered simply by 1/2 with the provided quantity. Hence, in the case of the particular acetate ester, should you insert One hundred mg (mgs) regarding acetate then right after 72 hours (period of time of 50 percent life) you will have 50mgs nonetheless contained in our bodies; then right after 3 more times simply 25mg, etc.


Supply Raw Oxyemetholone Steroid Powders With Delivery Safety Ensure


Oxyemetholone is a powerful Di-hydrotestosterone (DHT) produced anabolic steroid generally marketed under the well-liked business identify Anadrol. Designed to deal with serious muscle tissue wasting ailments, this can be among the premier bulk creating steroid drugs available on the market and has recently been considering that the Fifties. A robust mass builder, a characteristic many Dihydrotestosterone based anabolic steroids usually do not carry, Oxymetholone because you can have got thought is perfect for off-season bulking cycles, however it includes a slicing use as well, but in both cases, it really is largely misinterpreted. Most of the misunderstandings surrounding hormone agent comes from internet fantasy and also tale, with a simple glimpse we are going to established the facts totally free.

Consider this kind of treatments orally having a cup of water. Adhere to guidelines around the prescription tag. Take the treatments from normal time periods. Do not take on it more often than directed. Usually do not stop taking except on your dermatologist’s guidance.

Confer with your pediatrician about the usage of this particular medication in youngsters. Although this medicine could be recommended for selected conditions, safeguards carry out apply.

Patients over Sixty-five yrs . old will have a more powerful effect and need a smaller serving.

What must i inform my personal physician prior to My partner and i get this medicine?

They should determine you’ve got any of these conditions:

breast cancers
diabetic issues
high cholesterol
elimination disease
lean meats illness
prostate cancer
an unusual or hypersensitive reaction to oxymetholone, some other drugs, food items, fabric dyes, or perhaps preservatives
expectant or trying to get pregnant
breast-feeding


Supply Nandrolone Decanoate Raw Steroid Powders With Domestic Delivery Service


Nandrolone Decanoate or perhaps nandrolone decanoate, could very well be the particular second-best known injectable steroid ointment after testosterone. It seems that almost every steroid ointment newbie and many who’re experienced with steroid ointment series believe that for the best final results they could need to include Deca. Nevertheless, in reality this kind of compound does not have any specific anabolic properties: other injectable anabolic steroids can do every thing for muscle development that Deca may.
Rise in popularity ofNandrolone DecanoateThe strange properties of Nandrolone Decanoate result from the father or mother steroid ointment, nandrolone, also known as 19-nortestosterone. One of the main good attributes of nandrolone is that it has fairly reduced the conversion process to oestrogen compared to testosterone.

Inside before many years, androgenic hormone or testosterone and also nandrolone were the sole pharmaceutical drug injectables that were each accessible to be able to muscle builders and economical. Excess estrogen control failed to after that are present. For that reason, Deca’s reduced aromatizing attributes have been then quite beneficial. Deca as a result earned broad popularity.

An additional advantage associated with Nandrolone Decanoate (nandrolone) is that this compound is relatively moderate in terms of undesirable unwanted effects on the scalp as well as skin. This is because the actual 5-alpha reductase chemical functions to lessen great and bad nandrolone, during contrast a number of other anabolic steroids are usually untouched with this enzyme, and testosterone’s strength is in fact elevated because of it.

More, exactly where sports athletes have joint pain, in many cases usage of Deca in a steroid ointment period gets the good complication regarding providing some support. Also doses as little as One hundred mg/week may completely be enough for this function in most cases.

Regrettably, Nandrolone Decanoate utilization very commonly gets the adverse side-effect regarding upsetting healing of normal androgenic hormone or testosterone creation after a steroid ointment period. Adverse side-effect about sex drive and/or erectile function can also be frequent, however typically only when serving is at the very least 200-400 mg/week or perhaps when the medicine is utilized alone at virtually any efficient dose. Complaints are even worse any time Deca isn’t along with testosterone or perhaps significant dosages more androgenic ingredients including trenbolone, Masteron, or perhaps Dianabol. There’s extensive individual variation responding with regard to unwanted effects upon libido and also erections. Depression regarding disposition can be feasible.
Hence My partner and i typically advise towards Nandrolone Decanoate make use of besides the location where the sportsperson currently recognizes that he is able to encounter joint relief from the particular compound, or even he needs to find out if that will be the situation regarding him or her and the man knows the possible adverse unwanted effects. I favor regarding Deca make use of to become as little as is beneficial for almost any these kinds of joint problems, but for the majority of the overall steroid dose to be from other substances.

The actual extended half-life of the medicine results in gradual discounted. Because of this, Nandrolone Decanoate will be unsuited to be able to short series or even in which medication exams are a possibility. Furthermore, i look at the drug an unhealthy choice for women due to being at least because virilizing for every milligram since many other steroids other than testosterone as well as getting too long to if side-effects occur.


Hot Sale High Purity Testosterone Steroids With Doemstic Delivery Service


There are numerous advantages to androgenic hormone or testosterone use and while they are generally the same for anybody who uses they may be largely serving dependent in-terms from the general impact. Many men who use testo-sterone simply do in order a part of any hrt program; the thought would be to increase androgenic hormone or testosterone ranges to some typical variety when they possess decreased brief. Many other men utilize testo-sterone for an entirely different purpose; to boost ranges far beyond regular so they can improve performance. Regardless of your own purpose you can expect to get the following benefits to at least one level or any other:

Elevated Recuperation Abilities: One of the most likely illustration requires training/exercise. The action of instruction just isn’t any time muscle tissue is created but rather torn down; it is through the process of recovery in-which muscle tissues is built. Testosterone will heighten the rate regarding healing, enhance the performance of recuperation in-turn resulting in an even more successful and also able physique.

More robust Anti-Catabolic Safety: several the body’s hormones have a negative effect on muscle tissues and may advertise excess fat; perhaps most obviously will be the hormone cortisol. Testosterone can certainly help within obstructing as well as decreasing this particular damaging endocrine effect ensuring the muscles cells is protected and body excess fat is not gathered.

Improve Red Bloodstream Cellular Depend: Testosterone can tremendously enhance your endurance; the larger the staying power can lead to the opportunity to do more work, my partner and i.at the. teach. With this increase in red-colored blood vessels tissue we are able to increase the amount of air entering the actual blood vessels which usually raises working abilities and will result in greater muscle tissues efficiency.

Elevated Proteins Effectiveness: Through supplementing with androgenic hormone or testosterone we all improve necessary protein functionality, therefore enhancing the level and price in-which all of us build muscle cells or perhaps prevent leakages inside a caloric constrained diet regime. More, we’re able to conserve a higher-level associated with necessary protein storage space in-part due to an increase in nitrogen production as a result of higher amounts of androgenic hormone or testosterone.

They’re just about all good attributes in order to extra or exogenous testosterone use as well as the same effects can be achieved no matter the type of androgenic hormone or testosterone we all utilize. Whilst these aren’t the only good traits these are the many fundamental to our procedure as well as essential to the objectives spinning close to testo-sterone use.


Hot Sale High Purity SARMs Steroids With Domestic Delivery Service


SARMS, or perhaps picky androgen receptor modulators, certainly are a unique form of molecules that are getting developed to deal with diseases which can be increasingly being treated with AAS (anabolic-androgenic steroids). Some SARMS have got actually gone to trial regarding TRT (androgenic hormone or testosterone alternative treatment). Any time SARMS bind to the receptor they show anabolic and also hypertrophic action in the muscle and also bone fragments. This makes them ideal candidates for TRT, weak bones therapy and also muscle tissue throwing away remedy. With regard to body builders, SARMS give you the great things about conventional AAS (anabolic-androgenic steroids) : much more muscle tissue, less body fat, and bone density while generating considerably less unwanted effects (oestrogen associated sides and also bloating). SARMS can have a good anabolic to androgenic ratio as high as a 10:One. This is what lets them build muscle together with virtually no negative effects. Additionally they typically exhibit a top bioavailability, making certain successful utilisation and also assimilation.
Making use of anabolic steroids to boost the hormones is much like trying to tweak a microchip using a sledgehammer. Steroids assist you to build muscle simply by growing androgenic hormone or testosterone, which boosts proteins activity in your tissues, muscle building as well as shedding fat. That is regarded the actual anabolic side of anabolic steroids, and it’s fantastic.
However anabolic steroids also interact with your liver, the prostate gland, your coronary heart, your own sex organs (which ends up in basketball pulling in males and also clitoral enhancement in women), as well as your extra sexual intercourse qualities (tone of voice depth, hair growth, gynecomastia, zits, and so forth.). All these unwanted effects will be the androgenic a part of steroids.
The problem along with steroid drugs is they come with an anabolic-to-androgenic ratio of a single:1. Meaning they are equally as prone to, point out, shrink your balls or increase the size of your clitoris since they are to create muscle tissue : except if you’re taking bioidentical androgenic hormone or testosterone to keep up optimal hormonal levels, having a physician’s careful guidance (I have been doing this for a long time and I’ve didn’t have negative effects. Read concerning hacking androgenic hormone or testosterone here).
This is where SARMs innovate. They are far more discerning as compared to steroid drugs, featuring anabolic-to-androgenic ratios commencing with Three:One on and on of up to Ninety:A single. That means you may still obtain muscle mass progress and also fat loss, however SARMs is not going to provide you with gynecomastia or even turn you into the actual bearded girl. You may also take SARMs by mouth. Applications injection therapy.

China Factory Hot Sale Raw Masteron Steroid Powders For Bulking And Cutting


Masteron is a dihydrotestosterone (DHT) derived anabolic steroid. Specifically, Masteron is the DHT hormone that has been structurally altered by the addition of a methyl group at the carbon 2 position, This protects the hormone from the metabolic breakdown by the 3-hydroxysteroid dehydrogenase enzyme, which is found in the skeletal muscle. It also greatly increases the hormone’s anabolic nature. This simple structural change is all it takes to create Drostanolone, and from here the small/short Propionate ester is attached in order to control the hormone’s release time. Masteron can also be found through some underground labs, which does not have to be injected as frequently, but it is somewhat rare compared to the Propionate version. The majority of all Masteron on the market will be Drostanolone Propionate.

On a functional basis, Masteron is well-known for being one of the only anabolic steroids with strong anti-estrogenic properties. Not only does this steroid carry no estrogenic activity, but it can actually act as an anti-estrogen in the body. This is why it has been effective in the treatment of breast cancer. In fact, the combination of Masteron and Nolvadex (Tamoxifen Citrate) has been shown to be far more effective than chemotherapy in the treatment of inoperable breast cancer in postmenopausal women. This also makes it a popular steroid among bodybuilders as it could actually prohibit the need for an anti-estrogen when used in the right cycle. This will also prove advantageous during the cutting phase due to the hardening effects it can provide.

Masteron carries relatively low anabolic and androgenic ratings; however, these ratings are somewhat misleading. It’s important to remember DHT, the basis of Masteron, is five times more androgenic than testosterone with a much stronger binding affinity to the androgen receptor. This again promotes a harder look and can also enhance fat loss. Most all anabolic steroids are well-noted for enhancing the metabolic rate, but strong androgens have a tendency to directly promote lipolysis.

As an anabolic, Masteron isn’t well-known for promoting gains in lean muscle mass. It has never been used for muscle wasting in a therapeutic sense and will almost always be found in cutting plans among performance athletes. It can, however, promote significant boosts in strength, which could prove beneficial to an athlete who may not necessarily be looking for raw mass.


Testosterone Cypionate Steroid-Best Choice For Muscle Growth


Testosterone is a hormone produced by all human beings and is the primary male sex hormone. Through our discussion, well take a look at Testosterone Cypionate, and examine the pros and cons of its use to improve performance in athletics and bodybuilding. Before we dive in, lets clear up a common misconception. Testosterone Cypionate is no more or less powerful or effective than its counterpart Testosterone Enanthate. The two compounds are virtually identical in every way.

Testosterone Cypionate is a synthetic version of the naturally produced testosterone hormone. This hormone is responsible for many different physical and mental characteristics in males. It promotes sex drive, fat loss, helps with gaining and maintaining lean muscle mass, increases bone density, and may even protect against heart disease. Whether it is naturally produced or through the use of Testosterone Cypionate, these traits do not change. All other steroids are actually the testosterone molecule that has been altered to change the properties of the hormone.  Testosterone Cypionate carries a rating of 100 when measuring its anabolic/androgenic structure and this rating is used to measure all other steroids. This would make testosterone the “father” of all anabolic steroids used by athletes today.  It should be noted; all testosterone compounds, including Testosterone Cypionate carry this anabolic/androgenic score of 100, as they are all merely testosterone.

Testosterone Cypionate is a highly anabolic and androgenic hormone making it a great steroid to use if one is in pursuit of more size and strength. Testosterone Cypionate promotes nitrogen retention in the muscle and the more nitrogen the muscles hold the more protein the muscles store. Testosterone Cypionate can also increase the levels of another anabolic hormone, IGF-1 in muscle tissue providing even more anabolic activity. Testosterone Cypionate also has the amazing ability to increase the activity of satellite cells. These cells play an active role in repairing damaged muscle. Testosterone also binds to the androgen receptor to promote androgen receptor dependent mechanisms for muscle gain and fat loss.

Testosterone Cypionate induces changes in shape, size and can also change the appearance and the number of muscle fibers. Androgens like testosterone can protect your hard earned muscle from the catabolic (muscle wasting) glucocorticoid hormones, in-turn inhibiting the related adverse reactions. In addition, Testosterone Cypionate has the ability to increase red blood cell production and a higher red blood cell count will improve endurance through increased oxygenation in the blood. More red blood cells can also improve recovery from strenuous physical activity. Even so, Testosterones anabolic/androgenic effects are dose dependent; the higher the dose the higher the muscle building effect.

Many athletes display massive strength gains while using Testosterone Cypionate as the hormone improves muscle contraction by increasing the number of motor neutrons in muscle and improves neuromuscular transmission. It also promotes glycogen synthesis providing more fuel for intense workouts thereby increasing endurance and strength.

Test 600x Testosterone Cypionate also has the ability to promote fat loss through an enhancement of metabolic activity. Testosterone binds to the androgen receptor fairly well resulting in fat breakdown, and further prevents new fat cell formation. Another indirect action of fat loss that testosterone produces is the nutrient portioning effect it has on muscle and fat. Since the body is building muscle at an accelerated rate more of the food you eat is shuttled to muscle tissue instead of being stored as fat; nutrient efficiency is enhanced.

Testosterone Cypionate will also play a crucial role revolving around creatine. Creatine is essential to adenosine triphosphate (ATP), the source of energy for our muscles and when the muscles are stimulated ATP is broken down into adenosine diphosphate (ADP) and this is what releases energy. Unfortunately, the process is often too slow during strenuous activity but through the use of Testosterone Cypionate, this demand is met as ATP is replenished at a much faster rate.


What are the effects of Trenbolone Acetate?


Trenbolone Acetate is a 19-nortestosterone (19-nor) anabolic androgenic steroid. The 19-nor classification refers to a structural change of the testosterone hormone in that it lacks a carbon atom at the 19th position. This puts Trenbolone Acetate in the same category as Deca Durabolin (Nandrolone Decanoate). In fact, the Trenbolone hormone itself is simply a modified form of the Nandrolone hormone. The Trenbolone hormone carries a double bond at carbons 9 and 11, which in turn slows its metabolism, greatly increases its binding affinity to the androgen receptor, and inhibits it from aromatizing. The resulting change makes Trenbolone one of the most potent anabolic steroids of all time. Simply by looking at its structural ratings, we can begin to see how powerful it is. Trenbolone carries an anabolic rating of 500 and an androgenic rating of 500 is well. Such ratings are based on and measured against the ratings of testosterone, which carries a rating of 100 in both categories.

Trenbolone Acetate carries several powerful traits that are commonly associated with numerous anabolic steroids. However, while it carries numerous common traits, it also carries them at a rate of power and efficiency far above and beyond most steroids. Trenbolone Acetate also carries one trait that largely separates it from the rest of the pack and is what’s largely responsible for making it such a valuable hormonal compound.

Like numerous anabolic steroids, Trenbolone Acetate will greatly enhance protein synthesis and nitrogen retention in the muscle tissue. Protein synthesis refers to the rate by which cells build proteins; protein represents the primary building block of muscle. This will promote enhanced anabolism, as well as provide a strong protectant atmosphere during a caloric deficit. It will also largely promote a far greater level of recovery. As for nitrogen retention, the more nitrogen we retain the more anabolic we remain. Conversely, when nitrogen levels fall, this can lead to a catabolic or muscle wasting state. This is due to all lean muscle tissue being comprised of approximately sixteen percent nitrogen. While this is not a large amount, it is enough to make a very big difference. Once again, with enhanced nitrogen retention the anabolic atmosphere is greatly enhanced, tissue is preserved, and recovery is promoted.

Like many anabolic steroids, Trenbolone Acetate has the ability to greatly promote Insulin-Like Growth Factor-1 (IGF-1). IGF-1 is a powerful, naturally produced protein based hormone that is extremely anabolic, highly important to recovery and rejuvenation, and affects nearly every cell in the human body. IGF-1 plays a role on muscle tissue, ligaments and tendons, cartilage, the central nervous system, and the pulmonary system. There are very few anabolic steroids that will promote IGF-1 like Trenbolone Acetate.

Trenbolone Acetate also has the ability to greatly increase red blood cell count. Red blood cells are responsible for carrying oxygen to and through the blood. With an enhanced amount, this increases blood oxygenation. This will tremendously enhance muscular endurance and will once again greatly promote an enhanced rate of recovery. While Tren carries this trait, we cannot say it carries it in a manner that is above and beyond other anabolic steroids.

The final trait of Trenbolone Acetate is its ability to improve feed efficiency or what is sometimes referred to as nutrient efficiency. This is the precise reason why the hormonal compound is given to cattle. Food is the most important part of any plan, and the most anabolic substance we can consume. However, the body will only utilize each nutrient to a certain degree. The food in question will determine the rate of utilization. However, by including Trenbolone Acetate into a program, each nutrient consumed becomes more valuable, and the body is now able to utilize each nutrient to a higher degree. While the total intake of nutrients may not have changed, the body will be able to make better use of the same amount. The best way to look at it is like the money in your pocket. With one dollar you are able to buy one dollars worth of goods and services. Now imagine if you could take that same dollar and purchase ten dollars worth of goods and services. While perhaps a slight oversimplification, when it comes to the value of the nutrients you consume, this is essentially what Trenbolone Acetate will do.


Primobolan is one of the most popular cutting steroids


Pharmacologically, Primobolan is known as the hormone Methenolone or Methenolone Acetate. The latter is the chemical name of the active ingredient in Primobolan tablets. The Methenolone hormone is well recognized and quite popular. It is, in fact, most common among first-time body builders seeking to gain lean muscle before gaining more experience using performance-enhancing steroids.

Primobolan being a DHT-derivative, it holds many of the same properties of its parent hormone. For example its not aromatized by the aromatase enzyme into Estrogen at any dose. Therefore, any individual looking to utilize it should never experience any Estrogen related side effects from using it alone. This means that it completely avoids the potential for any of the following side effects: water retention and bloating, elevated blood pressure (as a result of water retention), possible fat gain/retention, and gynecomastia. Without the puffy and soft look that aromatizable anabolic steroids provide the physique, Primobolan is regarded by the majority of bodybuilders and athletes as a preferred ‘cutting’ compound considered very useful for pre-contest cycles and fat loss and cutting phases.

One of the features of Primobolan that deserves credit is the fact that it is a damn good androgen receptor. This simply means that it is good at enhancing the action of male hormones and counteracting the unwanted side effects of female hormones such as gynecomastia. Just this quality alone makes the steroid extremely sought-after in steroid-using circles. The steroid is preferred by many men who want to build muscles without running the risk of developing breasts. Using Primobolan means that people do not have to use anti-estrogen medication.

The steroid improves retention of nitrogen in the muscles which helps in creating of good quality muscle tissue. There are two forms of the steroid. It can either be taken orally or injected directly into the bloodstream. Both forms of the steroid are equally effective although the effects of orally ingested Primobolan may take longer to notice. Orally ingested primobolan is designed to pass through the liver unchanged. Men need 100 mg of the steroid per day whereas women need only 10 mg.


Best Sex Steroids Recommand For You


Sex steroids are crucial hormones for the proper development and function of the body; they regulate sexual differentiation, the secondary sex characteristics, and sexual behavior patterns. Sex hormones production is sexually dimorphic, and involves differences not only in hormonal action but also in regulation and temporal patterns of production. Gonadal sex steroids effects are mediated by slow genomic mechanisms through nuclear receptors as well as by fast nongenomic mechanisms through membrane-associated receptors and signaling cascades. The term sex steroids is nearly always synonymous with sex hormones. There are some common used sex steroids recommand for you as follows:

1.Tadalafil

Tadalafil (Cialis) is used to treat erectile dysfunction (ED, impotence; inability to get or keep an erection), and the symptoms of benign prostatic hyperplasia (BPH; an enlarged prostate) which include difficulty urinating (hesitation, dribbling, weak stream, and incomplete bladder emptying), painful urination, and urinary frequency and urgency in adult men. Tadalafil (Adcirca) is used to improve the ability to exercise in people with pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Tadalafil is in a class of medications called phosphodiesterase (PDE) inhibitors. It works to treat erectile dysfunction by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection. Tadalafil treats PAH by relaxing the blood vessels in the lungs to allow blood to flow more easily.

2.Sildenafil

Sildenafil relaxes muscles found in the walls of blood vessels and increases blood flow to particular areas of the body.Viagra is used to treat erectile dysfunction (impotence) in men. Another brand of sildenafil is Revatio, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women.Do not take Viagra while also taking Revatio, unless your doctor tells you to.

3.Vardenafil

Vardenafil is an oral drug that is used to treat impotence, the inability to attain or maintain a penile erection. It has a mechanism of action that is similar to sildenafil (Viagra), and tadalafil (Cialis). Penile erection is caused by the engorgement of the penis with blood. This engorgement occurs when the blood vessels delivering blood to the penis increase in size and increase the delivery of blood to the penis. At the same time, the blood vessels carrying blood away from the penis decrease in size and decrease the removal of blood from the penis. Sexual stimulation that leads to the engorgement and erection causes the production and release of nitric oxide in the penis. Nitric oxide then activates the enzyme, guanylate cyclase to produce cyclic guanosine monophosphate (cGMP). The cGMP is primarily responsible for increasing and decreasing the size of the blood vessels carrying blood to and from the penis, respectively. Vardenafil prevents an enzyme called phosphodiesterase-5 (PDE-5) from destroying cGMP so that cGMP persists longer. The longer cGMP persists, the more prolonged the engorgement of the penis. Vardenafil was approved by the FDA in August 2003.